Applikon® BioProduction Bioreactors
You rely on your equipment. Your equipment should rely on ATG.
When a bioreactor goes down, every minute of lost productivity matters—service must be both rapid and technically exact. Analytical Technologies Group specializes in the maintenance and repair of platforms such as the Applikon® BioProduction Sterilizable-In-Place Bioreactor Series, with field engineers trained to diagnose faults efficiently and implement targeted corrective actions. Supported by a tightly controlled in-house stock of essential spare parts, we minimize turnaround time and restore your system to full performance with minimal operational disruption.
Let’s get you up and running – and keep you there.
Tips for keeping your Applikon® BioProduction SIP Bioreactor in good working order:
Install inline filters on the gas supply lines feeding the controller (especially when using MFCs), and replace them annually.
If autoclaving is performed, maintain a log of autoclave cycles for the following:
Glass vessels
pH probes
DO probes
Any other probes located within the vessel
Adhere to the manufacturer’s specified autoclave life cycles and storage recommendations.
Replace vessel O-rings annually.
When using optical sensors, keep all open connections covered with the supplied protective caps to prevent fouling or contamination of connection points.
If the reactor will not be used for an extended period, power it down and, if possible, disconnect it from the power source. These systems rely on high-power electronics that generate significant heat, which can degrade components over time.
Have the impeller shaft drive assembly rebuilt annually to prevent component wear and potential contamination of the media.
Inspect the rollers in peristaltic pump heads for rolling resistance. They should rotate freely; remove any accumulated residue using a mild detergent to prevent tubing wear.
Perform annual preventive maintenance to verify that the system is operating in accordance with manufacturer specifications.
Having technical problems with your Applikon® BioProduction SIP Bioreactor?
Fast Response
We provide very prompt responses to customers within one business day.
Fast Turnaround
Our field service engineers are expediently dispatched across North America & Europe to fulfill your service request.
Expert Staff
ATG’s highly trained, highly skilled staff ensure your instruments remain in optimal condition.
Parts In Stock
To minimize instrument downtime, we stock virtually all parts for the systems in which we specialize.
Applikon® BioProduction SIP Bioreactors Troubleshooting Tips:
If process performance differs from pilot scale, reassess scale-up criteria (kLa, P/V, mixing time) rather than assuming linear scaling.
If oxygen transfer limits productivity, optimize mass transfer before increasing feed rates.
If gradients impact cell growth or product quality, evaluate mixing time and reactor hydrodynamics.
If batch-to-batch variability increases, standardize all pre-run and operational parameters.
If leaks are detected, inspect gaskets, clamps, and valve seats for wear or misalignment.
If valves fail to actuate correctly, verify pneumatic supply and diaphragm condition.
If abnormal vibration or noise occurs, inspect bearings, couplings, and structural supports.
If long campaigns are planned, implement preventative maintenance schedules based on runtime and validation requirements.
If feed rates deviate from setpoints, calibrate pumps under actual process conditions (pressure, viscosity, temperature).
If nutrient limitation occurs unexpectedly, verify feed composition, scheduling, and controller execution.
If feed lines contain air bubbles, re-prime and ensure airtight connections.
If tubing or pump components show wear, replace based on validated lifecycle intervals.
